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Estimated marginal means SEs of mood scores before and after 8, 24, 40, and 52 weeks of energy restriction with a low-carbohydrate, high-fat LC diet or a high carbohydrate, low-fat LF diet. Arch Intern Med. Changes in body weight, psychological mood and well-being Profile of Mood States, Beck Depression Inventory, and Spielberger State Anxiety Inventory scores, and cognitive functioning working memory and speed of processing were assessed. Both diets had similar effects on working memory and speed of processing. Weight loss as a result of dieting in obese individuals has been shown to reliably improve psychological state, including mood. Recently, we reported that 8 weeks of consuming either a hypocaloric LC diet or an isoenergetic conventional LF diet resulted in similar improvements in mood state in overweight and obese men and women. Over a longer period of 24 weeks, McClernon et al 14 reported that mood improved after weight loss with either an LC or an LF diet, but the improvements were greater with the LC diet owing to larger reductions in the negative affect that was suggested to be related to the antidepressant effects of a ketogenic diet. However, their study was limited in that mood was not assessed using validated scales. Rather, they used a symptom checklist developed by practitioners specifically for evaluating and treating individuals using an LC diet for weight loss that may have biased the result toward a positive effect of an LC diet as opposed to an LF diet. Also, the effects of an LC diet over the longer term remain unstudied, making it difficult to draw any definite conclusions regarding the long-term effects of an LC diet combined with moderate energy restriction on psychosocial health.