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I am taking levothyroxine to lose weight and I do not have a thyroid problem. What are some of the risk or problems I could encounter using this drug to lose weight? Levothyroxine is a synthetic thyroid hormone prescribed to treat low thyroid function, also known as hypothyroidism. Low thyroid function slows down the metabolism and this can lead to weight gain. Taking levothyroxine to treat hypothyroidism can help to normalise metabolism which may lead to weight loss. Levothyroxine contains a boxed warning saying that it should not be used for the treatment of obesity or weight loss. Taking levothyroxine for weight loss when not indicated can cause overdose symptoms. These symptoms include nervousness, insomnia, emotional swings, sweating, hand tremor, hair loss, sensitivity to warm temperatures feeling hot all the time, muscle weakness, shortness of breath, heart failure and angina, confusion and disorientation.